VDR is a gene which encodes for a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with lower bone mineral density in prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are look here responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and the temporal on-and-off occupancy of the VDRE between the two components. It is also influenced by chromosomal positioning and binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes carry an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) could be an archive of data and documents that are relevant to business, legal transactions or other processes. Viewing, downloading or printing are not permitted. It uses a central server and an extranet connection that is an Internet connection that has restricted access, to offer controlled log-on for set times when users can access the data and documents.
VDRs are most commonly used by investment banks and businesses involved in mergers and acquisitions. They need to be able to communicate information in a clear manner with potential investors or buyers. Due diligence procedures can also require a large amount of data. Life science firms also use VDRs for everything from clinical trials results to HIPAA documentation for compliance.
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